Masayuki Nagai
About Me
I’m a third-year Ph.D. student in Computational Biology at the Koo Lab, Cold Spring Harbor Laboratory. My research centers on developing methods to improve and interpret deep learning models in biology, with the goal of advancing our understanding of molecular and cellular mechanisms across genetics, epigenetics, and proteomics. This work aims to deepen our understanding of disease and to inform the design of more effective therapeutics. I’m also deeply committed to the responsible development of these technologies, with a focus on biosecurity and AI alignment to mitigate dual-use risks and ensure their safe application.
Outside of research, I’m passionate about tennis and climbing mountains!
Interests
- Continual Learning: Refining causal understanding through perturbation data integration
- Active Learning: Identifying the most informative experiments to guide research
- Sequence Design: Engineering sequences with desired functional properties
- Biosecurity: Preventing misuse and mitigating dual-use risks of biological AI models
- Mechanistic Interpretability: Understanding the inner workings of deep learning models
News
- Aug 2025 Gave a talk on causal refinement for genomic deep learning models via Continual Learning at MLCB 2025 (YouTube).
- Aug 2024 Joined Peter Koo's group at Cold Spring Harbor Laboratory.
- Aug 2023 Started Ph.D. in the School of Biological Sciences, Cold Spring Harbor Laboratory.